Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors

A compound having the formula:

• ##STR14## the sterioisomers and pharmaceutically acceptable salts thereof, wherein:
• X is O;
• R.sub.1 is phenyl;
• phenyl optionally substituted with a total of 1 to 3 substituents each of which is independently selected from Br, Cl, F, I, CF.sub.3, C.sub.1 to C.sub.14 alkyl, NO.sub.2, phenyl naphthyl, C.sub.1 to C.sub.14 alkyl;
• or cycloalkyl of 3 to 6 carbon atoms;
• R.sub.3 and R.sub.4 independently represent H, C.sub.1 to C.sub.4 alkyl;
• phenyl;
• phenyl optionally substituted with 1 to 3 substituents each of which is independently selected from Br, Cl, F, I, CF.sub.3, C.sub.1 to C.sub.14 alkyl, NO.sub.2, phenyl, naphthyl, C.sub.1 to C.sub.14 alkyl, cycloalkyl of 3 to 6 carbon atoms;
• R.sub.5 is H, phenyl, benzyl, (C.sub.1 to C.sub.6 alkyl)phenyl, naphthyl, C.sub.1 to C.sub.12 alkyl, or C.sub.3 to C.sub.8 cycloalkyl;
• R.sub.7 is H, or a pharmaceutically acceptable cation;