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US 5,109,113 AGranted
Membrane anchor fusion polypeptides
AssigneesGenentech, Inc., New York University
InventorsIngrid W. Caras, Michael A. Davitz, Victor Nussenzweig, David W. Martin, Jr.
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Abstract
Novel fusions of a phospholipid anchor domain and a polypeptide heterologous to the anchor domain donor polypeptide are provided for industrial use. Therapeutic administration of the fusions enables the targeting of biological activity to cell membrane surfaces.
Claims10
A non-naturally occurring polypeptide comprising an mDAF amino acid sequence defining a glycophospholipid anchor attachment domain fused to a polypeptide heterologous to said mDAF amino acid sequence defining a glycophospholipid anchor domain.
Dependencies are inferred from the claim text.