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US 5,108,424 AGranted
Collagen-impregnated dacron graft
AssigneeMeadox Medicals, Inc.
InventorsHarmon Hoffman, Jr., Kemal Schankereli
Life of this patent
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Abstract
A collagen-impregnated vascular graft includes a porous synthetic vascular graft substrate formed by knitting or weaving with at least three applications of dispersed collagen fibrils. Plasticizers are incorporated into the collagen slurry before application and the slurry is applied in separate treatments by massage and flow through techniques, cross-linked by exposure to formaldhyde vapor and dried.
Claims17
A synthetic vascular graft comprising:
- a tubular flexible porous fabric graft substrate of a synthetic fiber having a porosity of less than about 3,000 ml/min-cm.sup.2 (purified water at 120 mm Hg);
- the graft substrate having on the inner surface and extending through the porous substrate to the outer surface cross-linked water-insoluble collagen fibrils admixed with a plasticizer for rendering the graft blood-tight and flexible, the collagen fibrils applied by application of an aqueous slurry of water insoluble collagen fibrils which has been massaged through the substrate and dried and cross-linked after application.
A synthetic vascular graft comprising:
- a tubular flexible porous polyethylene terephthalate fabric graft substrate having a porosity of less than about 3,000 ml/min-cm.sup.2 (purified water at 120 mm Hg);
- the inner surface having been treated with collagen fibrils admixed with a plasticizer which extends into the porous structure of the substrate and covers the outer surface;
- the collagen applied by depositing an aqueous slurry containing between about 0.5 to 5.0 weight percent water insoluble collagen fibrils and between about 4 to 12 weight percent plasticizer to the lumen of the graft and massaged through the substrate and dried and cross-linked.
Dependencies are inferred from the claim text.