Back to results
US 5,106,726 AGranted
Synthetic peptides specific for the detection of antibodies to HCV
AssigneeUnited Biomedical, Inc.
InventorChang Y. Wang
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeUnited Biomedical, Inc.
InventorChang Y. Wang
Estimating the term…
The present invention relates to a method for the detection in body fluids of antibodies to hepatitis C virus (HCV), also known as a non-A non-B hepatitis (NANBH) virus and to the diagnosis of NANBH by the use of a composition of synthetic peptides. Each of these peptides has an amino acid sequence corresponding to immunodominant regions of a fusion protein and a non-structural polypeptide of HCV, SOD/HCV C100 and a postulated HCV structural (core) protein. More specifically, the present invention is directed to the use of a group of synthetic peptides in a prescribed sequence or their analogues for the detection of antibodies to HCV in body fluids. The detection method includes an enzyme-linked immunosorbent assay (ELISA), and other forms of immunoassay procedures. The present invention also relates to a method for generating high titer antibodies to HCV in healthy mammals, including humans, by the use of compositions containing these synthetic peptides, analogues or mixtures thereof, in a free, conjugated or polymeric form as key components in synthetic vaccines for the prevention of non-A non-B hepatitis (NANBH).
A peptide composition comprising a peptide selected from the group consisting of Peptide I, III to IX, each peptide with an amino acid sequence as follows:
A peptide composition comprising Peptide II having an amino acid sequence as follows:
An ELISA test kit according to claim 28 wherein the solid phase is coated with a peptide composition comprising a segment of Peptide II and having an amino acid sequence selected from the group consisting of:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
A peptide having the amino acid sequence:
An ELISA test kit for the detection of antibodies to HCV or NANBHV or the diagnosis of HCV or NANBHV infection comprising:
An ELISA test kit for the detection of antibodies to HCV or NANBHV or the diagnosis of HCV or NANBHV infection comprising:
An ELISA test kit for the detection of antibodies to HCV or NANBHV or the diagnosis of HCV or NANBHV infection comprising:
An ELISA test kit for the detection of antibodies to HCV or NANBHV or the diagnosis of HCV or NANBHV infection comprising:
Dependencies are inferred from the claim text.