Method for spectroscopic diagnosis of tissue
AssigneeMassachusetts Institute of Technology
InventorsCarter Kittrell, Robert M. Cothren, Jr., Michael S. Feld
Life of this patent
Estimating the term…
Abstract
A method of diagnosis of the type of tissue in an artery, including distinguishing artery wall from atheromateous plaque is described, in which a catheter with one or more optical fibers is enclosed at a distal end by an optical shield transparent to light radiation and wherein the proximal end of the catheter and optical fibers are coupled to a source of optical radiation. The catheter is inserted into an artery until the optical shield is brought into contact with a suspected arterial lesion or other tissue to be diagnosed.
Claims24
A method of diagnosing material within a vascular lumen of a patient comprising:
- positioning a distal surface of a catheter adjacent to vascular tissue or other material within the lumen to be diagnosed;
- illuminating the tissue or material with a selected wavelength of light that is transmitted through an optical fiber extending through the catheter to induce fluorescence of said tissue without the presence of a fluorescence enhancing agent;
- transmitting radiation returning from the fluorescing tissue or material along the optical fiber to a proximal end of the catheter;
- and
- analyzing the fluorescent radiation returned from the fluorescing vascular tissue or material to diagnose the tissue or material.
A method of diagnosing vascular tissue or material within a vascular lumen of a patient comprising:
- providing a laser catheter with a plurality of optical fibers in which a distal end of the catheter is enclosed by an optical shield transparent to radiation such that a proximal end of the catheter and the optical fibers can be coupled to a laser or other light source;
- positioning the catheter relative to vascular tissue or material within the lumen such that the optical shield is brought into contact with the vascular tissue or material to be diagnosed;
- coupling a light source to at least one of said optical fibers to irradiate the tissue or material and induce fluorescence of the tissue or material without the presence of a fluorescence enhancing agent, the irradiation resulting in an emission of light from said tissue such that the emitted light is transmitted through at least one of said optical fibers to the proximal end of the catheter;
- and
- analyzing the transmitted light to diagnose a condition of the vascular tissue or material within the lumen.
A method of imaging vascular tissue comprising:
- providing a laser catheter with a plurality of optical fibers in which a distal end of the catheter is enclosed by an optical shield transparent to optical light radiation and wherein a proximal end of the catheter and the optical fibers can be coupled to a light source;
- positioning the catheter within a vascular lumen of a patient such that the optical shield is brought into contact with, or adjacent to, the vascular tissue;
- coupling the light source to at least one of said optical fibers to direct light onto the vascular tissue and induce fluorescence of the tissue without the presence of a fluorescence enhancing agent, the fluorescence resulting in an emission of light from said tissue such that the emitted light is transmitted through at least one of said optical fibers to the proximal end of the catheter;
- and
- forming an image of the fluorescing tissue.
A method of diagnosing material within a vascular lumen of a patient comprising:
- providing a laser catheter with a plurality of optical fibers extending from a proximal end to a distal end of the catheter such that a proximal end of the catheter and the optical fibers can be coupled to a laser;
- providing a computer in which a reference signal has been stored;
- positioning the distal end of the catheter within the vascular lumen of a patient such that the distal end is adjacent to material within a vascular lumen to be diagnosed;
- coupling the laser to the proximal end of at least one of said optical fibers;
- irradiating the tissue with laser radiation transmitted through the catheter to induce fluorescence of the tissue without the presence of a fluorescence enhancing agent, the irradiation of the vascular material resulting in an emission of fluorescent light from said material such that the emitted light is transmitted through at least one of said optical fibers to the proximal end of the catheter;
- detecting the emitted fluorescent light transmitted to the proximal end of the catheter and generating a spectral signal correlated with the detected light;
- and
- comparing the spectral signal with the reference signal to diagnose the irradiated vascular material.
Dependencies are inferred from the claim text.