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US 5,104,887 AGranted
Topical ophthalmic imino substituted 2-imino-3-methyl-delta4-1,3,4-thiadiazoline-5-sulfonamides carbonic anhydrase inhibitors
AssigneeUniversity of Iowa Research Foundation
InventorsRonald D. Schoenwald, Charles F. Barfknecht
Life of this patent
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Abstract
High potency carbonic anhydrase inhibitors derived from methazolamide.
Claims12
Methazolamide analogs of the structure:
- ##STR5## wherein n is an integer and is selected from 0, 1, 2, 3, 4, and 5, X is a moiety selected from the group of hydrogen, hydroxyl, hydroxymethyl, 2-hydroxyethyl, 2-hydroxyethoxy, Ar is a ring structure selected from phenyl, pyridyl, and furanyl, and m is a whole integer and is selected from 0, 1, 2, 3, and 4.
An analog of methazolamide of the following formula:
- ##STR6## where n is a whole integer and is selected from 0, 1, 2, 3, 4, and 5, X is a moiety selected from the group consisting of hydrogen, hydroxyl, hydroxymethyl, 2-hydroxyethyl, and 2-hydroxyethoxy, Ar is a ring structure selected from the group consisting of phenyl, pyridyl, and furanyl, and M is a whole integer selected from 0, 1, 2, 3, and 4.
A methazolamide analog of the following formula:
- ##STR7## wherein R is a C.sub.1 -C.sub.8 alkyl.
Dependencies are inferred from the claim text.