Certain bicycloalkane and azabicycloalkane-1,1-diphosphonic acid derivatives useful for treating diseases associated with abnormal calcium and phosphate metabolism
AssigneeThe Procter & Gamble Company
InventorsJames J. Benedict, Karen Y. Johnson, James J. Benedict, Karen Y. Johnson
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Abstract
This invention relates to pyrindine-diphosphonic acid derivatives which are useful in treating or preventing diseases characterized by abnormal calcium and phosphate matabolism, in particular those which are characterized by abnormal bone metabolism. This invention further relates to pharmaceutical compositions which contain the novel compounds of the present invention, and to a method of treating or preventing diseases characterized by abnormal calcium and phosphate metabolism utilizing a compound of the present invention.
Claims16
A cyclic diphosphonic acid having the structure:
- ##STR9## wherein R.sub.1 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, and alkoxy, said alkoxy having from 1 to 6 carbon atoms;
- wherein said R.sub.1 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy;
- R.sub.2 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, alkoxy, said alkoxy having from 1 to 6 carbon atoms, and nitro;
- wherein said R.sub.2 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy;
- and pharmaceutically-acceptable salts of said diphosphonic acids.
A cyclic diphosphonic acid having the structure:
- ##STR10## wherein R.sub.1 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, and alkoxy, said alkoxy having from 1 to 6 carbon atoms;
- wherein said R.sub.1 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy;
- R.sub.2 is one substituent selected from the group consisting of hydrogen, substituted or unsubstituted, saturated or unsaturated alkyl having from 1 to 6 carbon atoms, substituted and unsubstituted phenyl, substituted and unsubstituted naphthyl, substituted and unsubstituted benzyl, hydroxy, halogen, substituted and unsubstituted amino, amido, carboxy, carbonyl, alkoxy, said alkoxy having from 1 to 6 carbon atoms, and nitro;
- wherein said R.sub.2 groups, when substituted, are substituted with a group selected from methyl, amino, alkylamino, chloro, hydroxy, and methoxy;
- and pharmaceutically acceptable salts of said diphosphonic acids.
A cyclic diphosphonic acid having the structure:
- ##STR11##
A cyclic diphosphonic acid having the structure:
- ##STR12## and pharmaceutically-acceptable salts thereof.
Indan-2,2-diphosphonic acid, and pharmaceutically-acceptable salts thereof.
Dependencies are inferred from the claim text.