Pyrogens separations by ceramic ultrafiltration
AssigneeAluminum Company of America
InventorsJames L. Filson, Ramesh R. Bhave, James R. Morgart, James M. Graaskamp
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Abstract
The method of the present invention for separating pyrogens includes passing a pyrogen-containing liquid through a zirconium oxide membrane on a ceramic support. The membrane on ceramic support preferably includes a porous sintered zircondium oxide membrane on alpha-alumina support.
Claims18
A method of separating pyrogens comprising passing pyrogen-containing liquid through a zirconium oxide membrane on ceramic support, wherein said zirconium oxide membrane has a nominal pore size in the range of about 20.ANG. to 100.ANG..
A method of purifying a liquid to remove pyrogens comprising passing pyrogen-containing liquid through a ceramic membrane having a nominal pore size in the range of about 20.ANG. to 100.ANG. and further having a flux rate or permeability higher than about 40 L/hr/m.sup.2 / atm to remove pyrogens without substantial fouling of the membrane through a run time of at least 60 minutes.
A method of separating pyrogens comprising:
- (a) providing an acid depyrogenated, ultrafiltration membrane of porous sintered zirconia oxide having a nominal pore size in the range of about 20.ANG. to 100.ANG. on alpha-alumina support by treating said membrane on support with nitric acid;
- and
- (b) passing pyrogen-containing water by cross-flow or tangential filtration over and through said zirconia oxide membrane on alpha-alumina support to separate pyrogens and form a non-pyrogenic permeate.
Dependencies are inferred from the claim text.