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US 5,101,041 AGranted
Triamines and their derivatives as bifunctional chelating agents
AssigneeThe Curators of the University of Missouri
InventorsDavid E. Troutner, Christy S. John, Maroor R. A. Pillai
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Abstract
A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.
Claims6
A compound of the formula:
- ##STR11## wherein:
- R represents independently hydrogen, C.sub.1 -C.sub.3 alkyl, or benzyl;
- R.sup.1 represents ##STR12## Q represents hydrogen, C.sub.1 -C.sub.3 alkyl or phenyl;
- R.sup.2 represents hydrogen, --CH.sub.2 CO.sub.2 H, --CH.sub.2 CH.sub.2 CO.sub.2 H, or --(CH.sub.2).sub.2 NH.sub.2 ;
- m and n are independently 2, 3, or 4;
- L is a linker/spacer group covalently bonded to, and replaces one hydrogen atom of the nitrogen atom to which it is joined said linker/spacer group being represented by the formula ##STR13## wherein:
- Y is selected from the group consisting of nitro, amino, isothiocyanato, semicarbazido, thiosemicarbazido, carboxyl, bromoacetamido and maleimido;
- q is 1, 2, or 3;
- or
- a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.