Polyurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same

A polyurethane amide segmented copolymer useful for the manufacture of biomedical articles, having a general repeating unit [I] ##STR13## wherein R is hexamethylene, 4,4'-diphenylmethane, toluene, naphthalene, 4,4'-dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethyl-hexamethylene or p-phenylene,

• R' is selected from a linear or branched, unsubstituted or substituted hydrocarbyl group, said substituents being selected from halogen or hydroxy, or
• R' is a bivalent Si--(R.sub.1 R.sub.2) group, wherein R.sub.1 and R.sub.2 are identical or different groups selected from hydrogen, alkyl, a double bond-containing hydrocarbyl group, halogen, hydroxy or an aromatic ring-containing group, and
• m is a positive integer,
• A is a bivalent saturated or unsaturated, linear or branched, substituted or unsubstituted hydrocarbyl group, said substituents being selected from halogen, hydroxy, cyano, carboxy or amino groups, or
• A is an unsubstituted or substituted aromatic ring-containing group, said substituents being selected from halogen, hydroxy, cyano, carboxy or amino groups, and
• n is zero or a positive integer.

A polyurethane amide segmented copolymer useful for the manufacture of biomedical articles, having a general repeating unit [II]

• b) a segmented block polyurethane of the following repeating unit [II] ##STR14## wherein R is hexamethylene, 4,4'-diphenylmethane, toluene, naphthalene, 4,4' dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethyl-hexamethylene or p-phenylene,
• R is selected from a linear or branched, unsubstituted or substituted hydrocarbyl group, said substitutents being selected from halogen or hydroxy, or
• R' is a bivalent Si--(R.sub.1 R.sub.2) group, wherein R.sub.1 and R.sub.2 are identical or different groups selected from hydrogen, alkyl, a double bond-containing hydrocarbyl group, halogen, hydroxy or an aromatic ring-containing group, and
• m is a positive integer and
• B and D are each a bivalent, saturated or unsaturated, linear or branched, unsubstituted or substituted hydrocarbyl group, said substituents being selected from halogen, hydroxy, cyano, carboxy or amino groups, or
• B and D are each an unsubstituted or substituted aromatic ring-containing group, said substituents being selected from halogen, cyano, carboxy or amino groups wherein B and D can be the same or different, and
• a and b are identical or different and are each 0 or 1, and
• X and Y are identical or different grafted substituents, usually bearing biomedical relevance.