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US 5,100,917 AGranted
Novel A-nor-steroid-3-carboxylic acid derivatives
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsGary A. Flynn, Philippe Bey, Thomas R. Blohm
Life of this patent
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Abstract
The present invention relates to novel A-nor-steroid-3-carboxylic acid derivatives and to their use as inhibitors of mammalian 5.alpha.-reductase.
Claims15
A compound of the formula ##STR8## wherein the dotted line represents an optional double bond;
- R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl/cycloalkyl or --(CH.sub.2).sub.x -Ar-(M).sub.y, wherein x is 0, 1 or 2, Ar is phenyl, y is 0, 1 or 2, and M is C.sub.1 -C.sub.6 alkoxy, halogen, C.sub.1 -C.sub.6 alkyl/cycloalkyl, or --S(O).sub.z R.sub.5 wherein R.sub.5 is a C.sub.1 -C.sub.6 alkyl/cycloalkyl and z is 0, 1 or 2;
- and
- R.sub.2 is C.sub.1 -C.sub.6 alkyl alcohol;
- C.sub.1 -C.sub.6 alkyl aldehyde/ketone;
- CON(R.sub.3)(R.sub.4), wherein R.sub.3 and R.sub.4 are each independently, hydrogen or C.sub.1 -C.sub.6 alkyl/cycloalkyl, or --(CH.sub.2).sub.x -Ar-(M).sub.y, wherein x is 0, 1 or 2, Ar is phenyl, y is 0, 1 or 2, and M is C.sub.1 -C.sub.6 alkoxy, halogen, C.sub.1 -C.sup.6 alkyl, or --S(O).sub.z R.sub.5 wherein R.sub.5 is a C.sub.1 -C.sub.6 alkyl/cycloalkyl and z is 0, 1 or 2.
2 more elements
Dependencies are inferred from the claim text.