Cyclic amine compounds and pharmaceutical use

A compound having the formula ##STR327## in which J is selected from the group consisting of ##STR328## in which t is an integer of 1 to 4 and S is selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, and, when t is 2, (S).sub.t can be methylenedioxy or ethylenedioxy connected to two adjacent carbon atoms on the phenyl ring, B is selected from the group consisting of --(CHR.sup.22).sub.r --, --CH.dbd.CH--(CHR.sup.22).sub.r --, .dbd.(CH--CH.dbd.CH).sub.b, .dbd.CH--(CH.sub.2).sub.c -- and .dbd.(CH--CH).sub.d .dbd., R.sup.22 is hydrogen or methyl, r is zero or an integer of 1 to 10, b is an integer of 1 to 3, c is zero or an integer of 1 to 9 and d is zero or an integer of 1 to 5:

• K is hydrogen, phenyl, substituted phenyl, phenylalkyl, phenylalkyl having a substituent on the phenyl ring, cinnamyl, lower alkyl, pyridylmethyl, cycloalkylalkyl, adamantanemethyl, furylmethyl, cycloalkyl, alkoxycarbonyl or acyl;
• and
• indicates a single bond or a double bond, with the proviso that J is not ##STR329## when B is --(CHR.sup.22).sub.r --, or a pharmacologically acceptable salt thereof.

A compound having the formula ##STR330## wherein c is zero or an integer of 1 to 9, S is hydrogen or a substituent on the phenyl ring, and t is an integer of 1 to 4, with the proviso that (S).sub.t can be a methylenedioxy group or an ethylenedioxy group joined to two adjacent carbon atoms of the phenyl ring;

• and
• K is hydrogen, phenyl, substituted phenyl, phenylalkyl, phenylalkyl having a substituent on the phenyl ring, cinnamyl, lower alkyl, pyridylmethyl, cycloalkylalkyl, adamantanemethyl, furylmethyl, cycloalkyl, alkoxycarbonyl or acyl,
• or a pharmacologically acceptable salt thereof.

A compound having the formula ##STR331## wherein t is an integer of 1 to 4, and S is selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, and, when t is 2, (S).sub.t can be methylenedioxy or ethylenedioxy connected to two adjacent carbon atoms on the phenyl ring, or a pharmacologically acceptable salt thereof.

A compound having the formula ##STR332## wherein J is ##STR333## t is an integer of 1 to 4 and S is selected from the group consisting of hydrogen, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 carbon atoms, and, when t is 2, (S).sub.t can be methylenedioxy or ethylenedioxy connected to two adjacent carbon atoms on the phenyl ring;

• when J is ##STR334## B is --CH.dbd.CH--(CHR.sup.22).sub.r 13 wherein r is zero or an integer of 1 to 10 and R.sup.22 is hydrogen or methyl, and when J is ##STR335## B is selected from the group consisting of .dbd.(CH--CH.dbd.CH).sub.b -- wherein b is an integer of 1 to 3, .dbd.CH--(CH.sub.2).sub.c -- wherein c is zero or an integer of 1 to 9 or .dbd.(CH--CH).sub.d -- wherein d is zero or an integer of 1 to 5;
• and K is selected from the group consisting of phenyl, substituted phenyl, arylalkyl, ring-substituted arylalkyl, alkylcycloalkyl, cinnamyl, benzoyl and ring-substituted benzoyl,
• indicates a single or double bond, or a pharmacologically acceptable salt thereof.