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US 5,099,037 AGranted
2,19-methyleneoxy and 2,19-methylenethio bridged steroids as aromatase and 19-hydroxylase inhibitors
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsNorton P. Peet, J. O'Neal Johnston, Joseph P. Burkhart
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Abstract
The present invention is directed to a group of compounds which are 2,19-methylenoxy or 2,19-methylenethio bridged steroids, and related steroidal compounds. These compounds are useful as aromatase and 19-hydroxylase inhibitors.
Claims6
A compound of the formula
- wherein
- represents a single or double bond, provided there is at least one double bond,
- A is O, S, SO, or SO.sub.2 ;
- R is H, .alpha.CH.sub.2, .dbd.O, or --OH;
- R.sup.1 is H or C.sub.1-4 alkyl;
- R.sup.2 is .dbd.O, --OH, --O--(C.sub.1-4 alkanoyl);
- and
- X is .dbd.O, .dbd.CH.sub.2, --OH, or --O--(C.sub.1-4 alkanoyl).
5 more elements
Dependencies are inferred from the claim text.