Propanobicyclic amine derivatives for CNS disorders

A pharmaceutical composition comprising a therapeutically-effective amount of an active compound for treating or preventing a CNS-related disorder and a pharmaceutically-acceptable carrier or diluent, said active compound selected from a family of compounds of the formula ##STR41## wherein X is ##STR42## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aryloxy, aralkoxy, alkoxyalkyl, halo, haloalkyl, hydroxyalkyl, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkanoyl, alkoxycarbonyl, alkenyl and alkynyl;

• wherein R.sup.3 and R.sup.4 may be taken together to form oxo;
• wherein each of R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, cycloalkylalkyl, alkoxyalkyl, aralkyl, aryl, alkenyl, alkynyl, alkenylalkyl, alkynylalkyl, carboxyalkyl, alkanoyl, alkoxycarbonyl, carboxy, cyanoalkyl, alkylsulfinyl, alkylsulfonyl, arylsulfinyl and arylsulfonyl;
• wherein R.sup.11 and R.sup.12 may be taken together to form oxo;
• wherein R.sup.13 and R.sup.14 may be taken together to form oxo;
• wherein G is selected from ##STR43## wherein each of R.sup.16 and R.sup.17 is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aralkoxy, aryloxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, halo, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkoxycarbonyl and alkanoyl;
• wherein R.sup.16 and R.sup.17 may be taken together to form oxo;
• wherein m is one or two;
• wherein p is a number selected from zero through four, inclusive, wherein each of q and r is a number independently selected from one through five, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive;
• with the further proviso that X must be attached at a position selected from ring-position two, ring-position three and ring-position four;
• or a pharmaceutically-acceptable salt thereof.

A method for treating a patient afflicted with or susceptible to a CNS-related disorder, which method comprises administering to the patient a therapeutically-effective amount of a compound of the formula ##STR48## wherein X is ##STR49## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, Y and Z is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aryloxy, aralkoxy, alkoxyalkyl, halo, haloalkyl, hydroxyalkyl, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkanoyl, alkoxycarbonyl, alkenyl and alkynyl;

• wherein R.sup.3 and R.sup.4 may be taken together to form oxo;
• wherein each of R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13 and R.sup.14 is independently selected from hydrido, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, cycloalkylalkyl, alkoxyalkyl, aralkyl, aryl, alkenyl, alkynyl, alkenylalkyl, alkynylalkyl, carboxyalkyl, alkanoyl, alkoxycarbonyl, carboxy, cyanoalkyl, alkylsulfinyl, alkylsulfonyl, arylsulfinyl and arylsulfonyl;
• wherein R.sup.11 and R.sup.12 may be taken together to form oxo;
• wherein R.sup.13 and R.sup.14 may be taken together to form oxo;
• wherein G is selected from ##STR50## wherein each of R.sup.16 and R.sup.17 is independently selected from hydrido, hydroxy, alkyl, cycloalkyl, cycloalkylalkyl, aralkyl, aryl, alkoxy, aralkoxy, aryloxy, alkoxyalkyl, haloalkyl, hydroxyalkyl, halo, cyano, amino, monoalkylamino, dialkylamino, carboxy, carboxyalkyl, alkoxycarbonyl and alkanoyl;
• wherein R.sup.16 and R.sup.17 may be taken together for form oxo;
• wherein m is one or two;
• wherein p is a number selected from zero through four, inclusive, wherein each of q and r is a number independently selected from one through five, inclusive, with the proviso that sum of q and r is a number from three through six, inclusive;
• with the further proviso that X must be attached at a position selected from ring-position two, ring-position three and ring-position four;
• or a pharmaceutically-acceptable salt thereof.