Stable stannous chloride composition for labeling with radioactive technetium
AssigneeNihon Medi-Physics Co., Ltd.
InventorsMakoto Azuma, Jun Takahashi, Hirohiko Yamauchi, Nobuo Ueda
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Abstract
A non-radioactive labeling composition for preparation of a technetium 99m-labeled radioactive diagnostic agent, which comprises a small amount of a lyophilized product obtained from a stannous chloride solution having a high concentration of stannous chloride charged in a container.
Claims12
A reductive composition in a dry solid state usable on labelling with technetium 99 m, which comprises a product obtained by lyophilizing an aqueous solution of stannous chloride charged to a container in an amount of not more than 500 microliters, said solution containing stannous chloride in a concentration of not less than 0.5 mol/liter and prepared by dissolving stannous chloride alone in an aqueous solvent which is selected from the group consisting of water or its mixture with methanol, ethanol or dimethylsulfoxide.
A process for preparing a reductive composition in a dry solid state usable on labelling with technetium 99 m, which comprises preparing an aqueous solution containing stannous chloride in a concentration of not less than 0.1 mol/liter by dissolving stannous chloride alone in an aqueous solvent, charging said solution to a container in an amount of not more than 500 microliters, subjecting the contents of the container to lyophilization and then sealing the container;
- said aqueous solvent being selected from the group consisting of water or its mixture with methanol, ethanol or dimethylsulfoxide.
A process for preparing a reductive composition in a dry solid state usable on labelling with technetium 99 m, which comprises the steps of:
- (a) preparing a solution of stannous chloride in a concentration of not less than 0.5 mol/liter by dissolving stannous chloride alone in water,
- (b) charging the solution prepared in step (a) to a container in an amount of not more than 500 microliters, and
- (c) lyophilizing to provide stannous chloride in a dry solid state in said container.
A process for preparing a technetium 99 m-labeled radioactive diagnostic agent, which comprises the steps of:
- (a) preparing a solution of stannous chloride in a concentration of not less than 1.0 mol/liter by dissolving stannous chloride alone in water,
- (b) charging the solution prepared in step (a) to a container in an amount of not more than 500 microliters,
- (c) lyophilizing to provide stannous chloride in a dry solid state in said container,
- (d) adding water to said container to dissolve the stannous chloride therein, and
- (e) admixing 99 m-technetium in a pertechnetate form.
Dependencies are inferred from the claim text.