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US 5,093,498 AGranted
Trifluoromethylbenzyl containing quaternary salts
AssigneeMerck & Co., Inc.
InventorsUlf H. Dolling, Seemon H. Pines, Edward J. J. Grabowski
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Abstract
A process is disclosed for obtaining manipulated proportions of the (+) and (-) enantiomers of [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]aceti c acid by asymmetric chiral phase transfer catalysis.
Claims1
A catalyst having the formula:
- A--X
- wherein A is benzylcinchoninium, benxylcinchonidinium, benzylquininium, benzylquinidinium or the dihydro analogs thereof, wherein A is substituted on the phenyl part of the benzyl group with CF.sub.3 [or with chlorine on the 3 and 4 positions,]and the anionic species X is halo, hydroxy or other simple anion.
Dependencies are inferred from the claim text.