Tick-derived amblyommin and method of antithrombin therapy
AssigneeHoechst Aktiengesellschaft
InventorsWerner Bonin, Paul Habermann, Dominique Tripier, Elisabet Wohner
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Abstract
The invention relates to a new active substance--amblyommin--for anticoagulant therapy and to a process for the isolation thereof from hard ticks. The isolated protein having a thrombin-inhibitory action has a molecular weight of 20000 to 30000 dalton, an isoelectric point between 5.05 and 5.65 and the partial amino acid sequences Ile-Leu-Phe-Thr-Gln-Gly-Asn-X-Gly-Glu-Leu-Glu-Asn-X-Phe-Glu-, Lys-Ile-Leu-Phe-X-Gln-Gly- and Ala-Ser-Tyr-Ile-Val-X-Ser-Glu-Ser-Ile-Gln-Ile-Leu-X-Leu-Ser-Glu-Gly-Ile- in which each radical X can be identical or different and each represents a naturally occurring amino acid.
Claims7
An isolated protein having a thrombin-inhibitory action or a pharmaceutically acceptable salt thereof, the protein being isolated from hard ticks and having a molecular weight of 20,000-30,000 daltons as determined by gel filtration, and an isoelectric point between 5.05 and 5.65.
Dependencies are inferred from the claim text.