Dialysates for treating aids and arc and for otherwise increasing immune response
AssigneeImreg, Inc.
InventorA. A. Gottlieb
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Abstract
Purified human leukocyte dialysates are described for treatment of AIDS, ARC, and other immunodeficient conditions. The dialysates are purified by HPLC processes, and are made available in a form that is free of endotoxin and pyrogen. A dialysate designated Beta-1.11 is found by amino acid sequencing to consist essentially of endogenous Tyr-Gly. A dialysate designated Beta-1.12 is found by amino acid sequencing to consist essentially of endogenous Tyr-Gly-Gly.
Claims18
A purified human leukocyte dialysate, purified of substantially all endotoxin and pyrogen, possessing intrinsic immunoamplifier activity, wherein substantially all of said activity resides in one or more substantially pure materials having M.W.<500.
A preparation having a standardized immunoamplifier activity, said preparation comprising a mixture of purified human leukocyte dialysates having intrinsic immunoamplifier activity, said activity residing in substantially pure immunoamplifier materials having M.W.<500, wherein said preparation has been standardized for immunamplifier activity by dilution thereof from a more concentrated preparation of said dialysates until the preparation contains a predetermined per-unit quantity of Tyr-Gly, said preparation having been purified of substantially all endotoxin and pyrogen.
A preparation having a standardized immunoamplifier activity, said preparation comprising a purified human leukocyte dialysate having intrinsic immunoamplifier activity, said activity residing in a first substantially pure immunoamplifier material, said first material having M.W.<500 and being characterized by presence of the amino acid residue Tyr-Gly and no other amino acid groups, wherein said preparation has been standardized for immunoamplifier activity by dilution thereof from a more concentrated preparation of said dialysate until the preparation contains a predetermined per-unit quantity of Tyr-Gly, said preparation having been purified of substantially all endotoxin and pyrogen.
Dependencies are inferred from the claim text.