Antigenic epitopes of IgE present on B cell but not basophil surface
AssigneeTanox Biosystems, Inc.
InventorTse-Wen Chang
Life of this patent
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Abstract
Antigenic epitopes associated with the extracellular segment of the domain which anchors immunoglobulins to the B cell membrane are disclosed. For IgE, the epitopes are present on IgE-bearing B cells but not basophils or the secreted, soluble form of IgE. The epitope can be exploited for diagnosis.
Claims11
An antibody which specifically binds to the extracellular segment of the membrane-bound domain of a membrane-bound immunoglobulin chain.
A monoclonal antibody which specifically binds to the extracellular segment of the membrane-bound domain of a human membrane-bound immunoglobulin chain.
Monoclonal antibody which specifically binds to the extracellular segment of the membrane-bound domain of human IgE but does not bind to human IgE on the surface of basophils and does not bind to secreted, soluble IgE.
A continuous stable cell line which produces a monoclonal antibody which specifically binds to the extracellular segment of the membrane-bound domain of human IgE but does not bind to human IgE on the surface of basophils and does not bind to secreted, soluble IgE.
An antibody that specifically binds to a peptide having the amino acid sequence
- Glu Leu Asp Val Cys Val Glu Glu ala Glu Gly Glu Ala Pro
- and modifications of the peptide in which amino acids have been deleted, inserted or substituted without detracting from the immunological properties thereof.
Dependencies are inferred from the claim text.