Protection against rhabdomyolysis-induced nephrotoxicity
AssigneeThe Administrators of the Tulane Educational Fund
InventorsPatrick D. Walker, Sudhir V. Shah
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Abstract
The present invention is directed to the in vivo use of compounds which prevent the generation of, effectively scavenge, or detoxify a reactive oxygen metabolite that mediates a toxic effect of rhabdomyolysis and myoglobinuria. The compounds of the invention can be used to prevent or reduce rhabdomyolysis-induced renal damage, and include but are not limited to free radical scavengers, iron chelators, oxidizable compounds, enzymes which metabolize reactive oxygen metabolites or their precursors, and biosynthetic precursors thereof.
Claims14
A method for protecting against or reducing the renal toxicity of rhabdomyolysis comprising administering in vivo to a patient in need thereof an effective dose of at least one compound which substantially prevents the generation of, effectively scanvenges, or detoxifies a reactive oxygen metabolite which mediates a nephrotoxic effect of rhabdomyolysis.
Dependencies are inferred from the claim text.