Activated polymers and conjugates thereof
AssigneeXoma Corporation
InventorsDayton T. Reardan, Dane A. Goff
Life of this patent
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Abstract
Macromolecular species such as enzymes, proteins, drugs, and solid supports which contain reactive carbonyl groups or groups which are readily converted to reactive carbonyl groups are modified by reaction with a compound of the formula ##STR1## in which R.sup.1 is H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl; R.sup.2 is C.sub.2 -C.sub.5 alkylene or (C.sub.1 -C.sub.4 alkoxy)-substituted C.sub.2 -C.sub.5 alkylene; R.sup.3 is ##STR2## R.sup.4 is H or C.sub.1 -C.sub.4 alkyl; n is at least 5; and m is zero or 1.
Claims19
A compound having the formula ##STR7## in which R.sup.1 is a member selected from the group consisting of H, C.sub.1 -C.sub.20 alkyl, phenyl, (C.sub.1 -C.sub.10 alkyl)-substituted phenyl, or phenyl-substituted C.sub.1 -C.sub.10 alkyl;
- R.sup.2 is a member selected from the group consisting of C.sub.2 -C.sub.5 alkylene and C.sub.1 -C.sub.4 alkoxy-substituted C.sub.2 -C.sub.5 alkylene;
- R.sup.3 is ##STR8## R.sup.4 is a member selected from the group consisting of H and C.sub.1 -C.sub.4 alkyl;
- R.sup.5 is a member selected from the group consisting of --N.dbd. and --N--;
- n is at least 5;
- m is zero or 1;
- and
- A is a residue of a macromolecular species bearing a reactive carbonyl group, said molecular species being a member selected from the group consisting of enzymes, coenzymes, immunoglobulins, immunotoxins, proteins, drugs and polymeric solid supports.
Dependencies are inferred from the claim text.