Adhesion of Mycoplasma pneumoniae and Mycoplasma hominus to sulfatide
OwnerHoward C. Krivan, Victor Ginsburg +1inventors
InventorsHoward C. Krivan, Victor Ginsburg, David D. Roberts
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Abstract
The invention is a carbohydrate receptor for Mycoplasma pneumoniae and Mycoplasma hominus and its use to detect mycoplasma in biological fluids and diseased tissue and cells. The receptor can be included in a composition having a pharmaceutically acceptable carrier. Methods are provided for purifying, detecting, or removing mycoplasma from diseased tissue or fluids. The receptor includes sulfatides, dextran sulfate, sialyloligosaccharides, and mixtures thereof.
Claims11
A receptor which is capable of binding to Mycoplasma hominus and Mycoplsma pneumoniae comprising a compound selected from the group consisting of compounds containing the structure SO.sub.3.sup.- -Gal.beta.1-1Ceramide.
A method for detecting a pathogen selected from the group consisting of Mycoplasma pneumoniae and Mycoplasma hominus comprising:
- immobilizing fetuin onto a suitable carrier;
- contacting a sample to be analyzed with the immobilized fetuin;
- and detecting the presence of the pathogen using an enzyme-dextran sulfate conjugate.
Dependencies are inferred from the claim text.