Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders

A method of inhibiting lipopolysaccharide-mediated tumor necrosis factor production by human mononuclear cells which comprises contacting LPS with Bactericidal/Permeability Increasing Protein in an amount effective to inhibit lipopolysaccharide-mediated tumor necrosis factor production by the mononuclear cells.

A method of inhibiting endotoxin-mediated stimulation of neutrophils or mononuclear cells which comprises contacting endotoxin-associated lipopolysaccharide (LPS) with a purified, endotoxin-free human Bactericidal/Permeability Increasing Protein (BPI) under conditions such that the BPI binds to endotoxin-associated LPS and thereby inhibits endotoxin-mediated stimulation of neutrophils or mononuclear cells.

A method of treating a subject suffering from a disorder selected from the group consisting of endotoxin-related shock, endotoxin-related disseminated intravascular coagulation, endotoxin-related anemia, endotoxin-related thrombocytopenia, endotoxin-related adult respiratory distress syndrome, and endotoxin-related renal failure which comprises administering to the subject a purified, endotoxin-free, human Bactericidal/Permeability Increasing Protein under conditions such that the Bactericidal/Permeability Increasing Protein binds to endotoxin-associated lipopolysaccharide and thereby inhibits lipopolysaccharide stimulation of neutrophils and mononuclear cells so as to thereby treat the subject.

A method of treating a subject suffering from endotoxin-related shock which comprises administering to the subject a purified, endotoxin-free, human Bactericidal/Permeability Increasing Protein under conditions such that the Bactericidal/Permeability Increasing Protein binds to endotoxin-associated lipopolysaccharide and inhibits endotoxin-related shock so as to thereby treat the subject.

A method of reducing the symptoms associated with a disorder which comprises administering to a subject in need thereof purified, endotoxin-free Bactericidal/Permeability Increasing Protein under conditions such that the Bactericidal/Permeability Increasing Protein binds to endotoxin-associated lipopolysaccharide and inhibits lipopolysaccharide stimulation of neutrophils and mononuclear cells so as to thereby reduce the symptoms associated with the disorder, the disorder being selected from the group consisting of endotoxin-related shock, endotoxin-related disseminated intravascular coagulation, endotoxin-related anemia, endotoxin-related leukopenia, endotoxin-related thrombocytopenia, endotoxin-related adult respiratory distress syndrome, and endotoxin-related renal failure.