Oxathi(SIV)azol-5-one compounds
AssigneeGlaxo Inc.
InventorsJoel E. Shaffer, Stephen A. Thomson
Life of this patent
Estimating the term…
Abstract
The present invention relates to the compounds of formula (I). ##STR1## wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.5-8 cycloalkyl, aryl-C.sub.1-4 alkyl, aryl or heteroaryl; or aryl or heteroaryl which is mono-, di-, or trisubstituted independently with halogen, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, amino or C.sub.1-4 alkyl mono or disubstituted amino, pharmaceutical formulations containing these compounds and their use as vasodilators in the treatment of cardiovascular disorders.
Claims12
A compound of formula (I) ##STR5## wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.5-8 cycloalkyl, aryl-C.sub.1-4 alkyl, heteroaryl or aryl or heteroaryl which is mono-, di-, or trisubstituted independently with halogen, nitro, C.sub.2-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, amino or C.sub.1-4 alkyl mono or disubstituted amino with the proviso that R.sup.1 can not be 4-bromophenyl or 2,3,4-trimethoxyphenyl, wherein said aryl is phenyl or naphthyl and said heteroaryl is a 5, 6 or 7 member heteroaryl ring interrupted by one or more N, S or O hetero atoms.
A method of treating a cardiovascular disorder by inducing vasodilation in a mammal suffering from said disorder comprising administration of an effective vasodilating amount of a compound of formula (I) ##STR6## wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.5-8 cycloalkyl, aryl-C.sub.1-4 alkyl, aryl or heteroaryl;
- or aryl or heteroaryl which is mono-, di-, or trisubstituted independently with halogen, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, amino or C.sub.1-4 alkyl mono or disubstituted amino, wherein said aryl is phenyl or naphthyl and said heteroaryl is a 5, 6 or 7 member heteroaryl ring interrupted by one or more N, S or O hetero atoms.
A pharmaceutical formulation comprising an effective vasodilating amount of a compound of formula (I) ##STR7## wherein R.sup.1 is C.sub.1-8 alkyl, C.sub.2-8 alkenyl, C.sub.5-8 cycloalkyl, aryl-C.sub.1-4 alkyl, aryl or heteroaryl;
- or aryl or heteroaryl which is mono-, di-, or trisubstituted independently with halogen, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, amino or C.sub.1-4 alkyl mono is disubstituted amino and a pharmaceutically acceptable carrier, wherein said aryl is phenyl or naphthyl and said heteroaryl is a 5, 6 or 7 member heteroaryl ring interrupted by one or more N, S or O hetero atoms.
Dependencies are inferred from the claim text.