Intermediates for the synthesis of 19-nor vitamin D compounds
AssigneeWisconsin Alumni Research Foundation
InventorsHector F. DeLuca, Heinrich K. Schnoes, Kato L. Perlman
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Abstract
New intermediate compounds that can be used effectively for the synthesis of a broad range of 1.alpha.-hydroxy-19-nor-vitamin D compounds. These novel intermediates are characterized by a group selected from hydroxy methyl (--CH.sub.2 OH), carboxaldehyde (--CHO), and carboxy ester (--COOAlkyl) at the carbon 22 position of the side chain of a 19-nor-vitamin D nucleus. Intermediates of this type are useful for the introduction of side chain units and thus represent important synthons for the preparation of many different 19-nor-vitamin D compounds.
Claims1
A compound of the formula
- where X.sup.1 and X.sup.2, which may be the same or different, represent hydrogen or a hydroxy-protecting group, and where R.sup.1 is selected from the group consisting of hydroxy-methyl, hydroxy-protected hydroxymethyl, carboxaldehyde (--CHO), and carboxyalkyl (--COOAlkyl).
Dependencies are inferred from the claim text.