Process for the preparation of azabicyclo compounds
AssigneeRoussel Uclaf
InventorsAbdul B. N. Luheshi, Robert K. Smalley, Peter D. Kennewell, Robert Westwood
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AssigneeRoussel Uclaf
InventorsAbdul B. N. Luheshi, Robert K. Smalley, Peter D. Kennewell, Robert Westwood
Estimating the term…
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X.sub.1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms or taken together with the carbon atom to which they are attached are ##STR2## Y is --O-- or --S--, R.sub.3 is alkyl of 1 to 3 carbon atoms or aryl of 6 to 8 carbon atoms, ##STR3## is selected from the group consisting of ##STR4## R.sub.4 and R.sub.5 are individually aryl unsubstituted or substituted with at least one member of the group consisting of halogen, --NO.sub.2 and alkyl and alkoxy of 1 to 3 carbon atoms and non-toxic, pharmaceutically acceptable salts thereof with acids and bases having cyclooxygenase inhibiting and antibiotic acitvity.
A process for the preparation of a compound selected from the group consisting of a compound of the formula ##STR21## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl and hydroxyalkyl of 1 to 5 carbon atoms and amino, n is an integer from 1 to 3, X and X.sub.1 are individually selected from the group consisting of hydrogen and alkyl of 1 to 3 carbon atoms or taken together with the carbon atom to which they are attached are ##STR22## Y is --O--or --S--, R.sub.3 is alkyl of 1 to 3 carbon atoms or aryl of 6 to 8 carbon atoms, ##STR23## is selected from the group consisting of ##STR24## R.sub.4 and R.sub.5 are individually aryl unsubstituted or substituted with at least one member of the group consisting of halogen, --NO.sub.2 and alkyl and alkoxy of 1 to 3 carbon atoms and non-toxic, pharmaceutically acceptable salts thereof with acids and bases comprising effecting a cyclo addition reaction between a compound of the formula ##STR25## is as defined above and a compound of the formula ##STR26## wherein R.sub.1, R.sub.2, n, X, X.sub.1, Y and R.sub.3 are as defined above to obtain the compound of formula I.
Dependencies are inferred from the claim text.