Crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid, and its preparation and uses
AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorsShuzo Sakai, Masaru Yoneyama, Toshio Miyake
Life of this patent
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Abstract
2-O-.alpha.-D-Glucopyranosyl-L-ascrobic acid is crystallizable in its supersaturated solution. Crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is substantially nonhygroscopic, free flowing, free of deliquescence, consolidation and direct reducing activity, but is readily soluble in water. Because of these, crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid is handleable with an ease, and superiorly high in stability and physiological activities. Thus, crystalline 2-O-.alpha.-D-glucopyranosyl-L-acorbic acid is favorably useful in vitamin C-enriching agents, foodstuffs, pharmaceuticals and cosmetics.
Claims27
A process to prepare crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid, said process comprising:
- providing a solution containing L-ascorbic acid and an .alpha.-glucosyl saccharide;
- allowing a saccharide-transferring enzyme alone or together with glucoamylase to act on the solution to form 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid;
- recovering and purifying the resultant 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid;
- preparing a supersaturated solution of 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid;
- crystallizing 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid in the supersaturated solution;
- and
- recovering the resultant crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid.
A foodstuff composition which contains foodstuff and a crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid.
A cosmetic composition comprising at least one cosmetic ingredient and further comprising a crystalline 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid.
A method for purifying 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid, said method comprising:
- providing a mixture containing 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid together with a water-soluble contaminant;
- separating said mixture using a water-insoluble carrier in accordance with molecular weight or affinity into at least two fractions;
- (i) a first fraction which is rich in 2-O-.alpha.-D-glucopyranosyl-L-ascorbic acid, and
- (ii) a second fraction which is rich in the contaminant;
- and
- recovering said first fraction.
Dependencies are inferred from the claim text.