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OwnerJack M. Shaw, Lawrence B. Schookinventors
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Acetylated low density lipoproteins are combined with active and effective lipophilic peptide or other lipophilic immunomodulators, antigens or vaccines to carry the same to macrophage specific targeted receptor mediated endocytosis sites in a living system for treatment of cancer, infection hyperimmune related diseases or deficiences, or to enhance vaccine induction of immunity. Such receptor mediated endocytosis sites are found on macrophages, monocytes and endothelial cells in organs and tissues of the body. The combination of acetyl-LDL and a lipophilic peptide or related lipophilic immunomodulators, antigens, polynucleotides or vaccines enables delivery of such to be made across vascular barriers by transcytosis. The penetration of endothelial blood-brain, eye or testicular barriers is included in this concept.
A method of preparing a noncovalently linked complex for targeted delivery to cells having acetyl-LDL (low density lipoprotein receptors comprising the steps of:
A complex comprising at least one active agent noncovalently complexed with a modified lipoprotein wherein the positive charge has been reduced by reaction at the epsilon amino group of lysine residues of the apoprotein.
Dependencies are inferred from the claim text.