Synthesis of hexahydrolupulone, novel forms thereof, and its use as a selective inhibitor of cell growth and multiplication
AssigneeKalamazoo Holdings, Inc.
InventorsPaul H. Todd, Jr., James A. Guzinski
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Abstract
A process for making hexahydrolupulone is described which involves the separation of beta acids from a hop extract, the removal of catalyst poisons from the beta acids, the hydrogenation of the beta acids to hexahydrolupulone, and the purification of the resulting hexahydrolupulone. Its use as an inhibitor of the growth of unwanted types of cells is described, as well as preferred forms for such use.
Claims7
A process for producing hexahydrolupulone which comprises the steps of contacting beta acids in an alkaline solution with a metal oxide, hydroxide, or salt which produces polyvalent metal ions, other than platinum or palladium, optionally in the presence of a water-immiscible solvent, separating the thus-purified beta acid alkaline solution from catalyst poisons present as solids or dissolved in the optional solvent, hydrogenating the purified beta acids at a pH above 4 with hydrogen using a platinum or palladium catalyst until uptake of three moles of hydrogen per mole of starting beta acids, and recovering hexahydrolupulone from the hydrogenation medium.
Dependencies are inferred from the claim text.