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US 5,082,785 AGranted
Biosynthesis of 2 keto-L-gulonic acid
AssigneeHoffmann-La Roche Inc.
InventorsRonald F. Manning, Maria S. Kahn
Life of this patent
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Abstract
A process of producing 2-keto-L-gulonic acid from sorbose via a recombinant bacteria including expression vectors and probes for producing said recombinant bacteria.
Claims3
A gluconobacter transformed with Tn5 which inactivates the 2-keto-L-Gulonic acid reductase and further having a recombinant plasmid which plasmid contains the DNA sequence effecting expression of L-sorbose dehydrogenase so that L-sorbose is converted to 2-KGA.
A gluconobacter transformed with Tn5 which inactivates the 2-keto-L-Gulonic acid reductase and which naturally produces L-sorbosone dehydrogenase but not L-sorbose dehydrogenase.
Dependencies are inferred from the claim text.