Cloned DNA sequences related to the entire genomic RNA of human immunodeficiency virus II (HIV-2), polypeptides encoded by these DNA sequences and use of these DNA clones and polypeptides in diagnostic kits
AssigneeInstitut Pasteur
InventorsMarc Alizon, Luc Montagnier, Denise Geutard, Francois Clavel, Pierre Sonigo, Mireille Guyader
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Abstract
A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probes are capable of hybridizing to the entire genome of HIV-2. These reagents also include polypeptides encoded by some of these DNA sequences.
Claims25
A peptide comprising immunological properties of a first portion of the envelope glycoprotein of a HIV-2 virus, wherein
- said peptide comprises no more than about 40 amino acid residues, said first portion of the envelope glycoprotein is antigenic or is capable of eliciting the production of antibodies directed to the peptide alone or when conjugated to a carrier molecule, and
- said envelope glycoprotein comprises an amino acid sequence substantially as follows:
- ##STR4##
The antigenic peptide gag1 comprising an amino acid sequence of the following formula:
- XNCKLVLKGLGMNPTLEEMLTAZ
- wherein X and Z are OH or NH.sub.2, or at least one of X and Z comprises a terminal group comprising from one to five amino acid residues, provided that the immunological properties of the peptide having the terminal group shall not be essentially modified from the peptide lacking the terminal group, and wherein each of the hyphens corresponds to an aminoacyl residue chosen from among those which permit the conservation of the immunological properties of the following peptide sequence:
- XNCKLVLKGLGMNPTLEEMLTA.
Dependencies are inferred from the claim text.