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US 5,079,167 AGranted
Method of racemate resolution
AssigneesGesellschaft fur Biotechnologische Forschung mbH (GBF), Degussa AG, Zweigniederlassung Wolfgang
InventorsClemens Sambale, Maria-Regina Kula, Werner Hummel, Karlheinz Drauz
Life of this patent
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Abstract
The invention relates to a method for resolving carbamate racemates of amino acids or norephedrine by enzmatic resolution.
Claims19
A method for resolving an amino acid carbamate racemate selected from the group consisting of a methyl carbamate of a DL-amino acid and an ethyl carbamate of a DL-amino acid, which comprises;
- enzymatic resolution of the racemate selected with an enzyme which cleaves the amide or the ester bond, in the selected racemate whereby stereoselective hydrolysis resolves one of the enantiomers of the DL-amino acid carbamate racemate, whereby there is obtained an anantiomer of the DL-amino acid.
A method for the resolution of a compound selected from the group consisting of racemic N-(methoxycarbonyl) norephedrine and racemic N-ethoxycarbonyl) norephedrine, which comprises;
- enzymatic resolution of the racemate selected with an enzyme which cleaves the amide bond in the selected compound, whereby stereoselective hydrolysis resolves one of the enantiomers oft he racemate and there is obtained an enantiomer of the norephedrine.
Dependencies are inferred from the claim text.