Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
AssigneeNeophore Technologies, Inc.
InventorBernard Ecanow
Life of this patent
Estimating the term…
Abstract
A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva, bodily fluids or other liquid comprising an interim skeletal structure of a watersoluble, hydratable gel or foam forming material, preferably a proteinaceous material, such as with maltodextran, in the hydrated state and dehydrated to leave spaces in place of hydration water. On dissolution by saliva, bodily fluids or other liquids, the composition becomes a liquid system. While the oral route is preferred, other routes may be used to administer the compositions of this method.
Claims33
A readily dissolvable carrier material having sufficient rigidity for administration of drugs, nutrients, vitamins, biologically-active materials, foodstuffs and combinations thereof capable of rapid dissolution by saliva comprising a porous skeletal structure of a water-soluble, hydratable gel or foam forming material that has been hydrated with water, rigidified in the hydrated state with a rigidifying agent in an amount, in proportion to the amount of gel or foam forming material, of about 0.1 to 5 times the weight of foam forming material, dry basis, and dehydrated with a liquid organic solvent at a temperature of about 0.degree. C. or below to leave spaces in place of hydration liquid.
A readily dissolvable, orally administrable solid, porous material containing a desired dosage of an active substance selected from the group consisting of a drug, nutrient, vitamin, biologically-active material, foodstuff, and combinations thereof capable of rapid dissolution when in contact with water or saliva and capable of delivering the active substance quickly to the bloodstream orally through the mouth tissue or gastrointestinal tract of an ingester of the material comprising a porous skeletal structure formed by freeze drying with a liquid organic solvent at a temperature of about 0.degree. C. or below a water-soluble, gel or foam material that was hydrated with water, rigidified sufficiently in the hydrated state with a rigidifying agent in an amount, in proportion to the amount of gel or foam forming material, of about 0.1 to 5 times the weight of foam forming material, dry basis, for handleability of the dried material, containing an effective amount of the active material absorbed or adsorbed within the skeletal structure.
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising the steps of:
- (a) freezing a solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material and water selected from the group consisting of coacervate phase water, equilibrium phase water and mixtures thereof;
- (b) contacting the frozen material of step (a) with the active material in an amount sufficient to cause the active material to be absorbed or adsorbed within the frozen material;
- (c) dehydrating the frozen material from step (b) by causing material transfer of water from the frozen material to an organic, liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0.degree. C. or below;
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- (d) removing the organic solvent from the dehydrated material resulting form step (c).
A method of manufacturing a carrier material having sufficient rigidity for carrying and administration of an active material selected from the group consisting of drugs, nutrients, vitamins, biologically-active compounds, foodstuffs, and combinations thereof comprising:
- (a) freezing a solution comprising a water-soluble gel or foam material and a monosaccharide or polysaccharide rigidifying agent for said gel or foam material and water;
- (b) dehydrating the frozen material from step (a) by causing material transfer of water from the frozen material to an organic, liquid solvent while both the frozen material and the organic solvent are held at a temperature of about 0.degree. C. or below;
- (c) removing the organic solvent from the dehydrated material resulting from step (b);
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- (d) adding to the carrier material, prior to freezing, an active material in an amount sufficient to cause the active material to be absorbed or adsorbed within the carrier material.
Dependencies are inferred from the claim text.