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AssigneesNew England Medical Center Hospitals, Inc., Wellesley College, Tufts College, Mit
InventorsPhilip E. Auron, Andrew C. Webb, Lee Gehrke, Charles A. Dinarello, Lanny J. Rosenwasser, Alexander Rich, Sheldon M. Wolff
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The subject invention concerns truncated human Il-1 cDNA sequences which encode biologically-active novel human IL-1 proteins. These truncated human IL-1 cDNA sequences can be obtained by genetic engineering procedures using a clone of human IL-1 cDNA, having the accession number NRRL B-15770, as a starting material. The truncated human IL-1 cDNA sequences of the subject invention are contained in specified plasmids whose constructions are described in detail. Biologically-active human IL-1 proteins are useful to induce the production of IL-2 by activated T-cells. They also act on B-cells and NK-cells.
cDNA coding for a truncated human IL-1 protein having the following sequence:
A recombinant DNA cloning vehicle comprising cDNA coding for a truncated human IL-1 protein of the amino acid sequence ##STR43##
Dependencies are inferred from the claim text.