Taste masking and sustained release coatings for pharmaceuticals
AssigneeMcNeil-PPC, Inc.
InventorEdward J. Roche
Life of this patent
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Abstract
Chewable medicament tablets are made from coated granules of a medicament wherein the coating on said granules comprises a blend of cellulose actate and/or cellulose acetate butyrate and hydroxypropyl cellulose and a process for making such tablets and a method of providing sustained release of medicaments utilizing such coated granules in a tablet.
Claims19
A chewable tablet of a medicament comprising compressed coated granules, said coated granules individually comprising medicament coated with from about 5 to about 28% of the total dry weight of the coated medicament granule of a polymer blend of:
- (a) cellulose acetate, cellulose acetate butyrate and combinations thereof;
- and (b) hydroxypropyl cellulose wherein the ratio of cellulose acetate, cellulose acetate butyrate and combinations thereof to hydroxypropyl cellulose is in the range of about 97/3 to about 50/50.
A process of preparing a chewable medicament tablet comprising the steps of:
- coating medicament granules with from about 5 to about 28% of the total dry weight of the coated medicament granule with a polymer blend of cellulose acetate, cellulose acetate butyrate or a combination thereof and hydroxypropyl cellulose wherein the ratio of cellulose acetate, cellulose acetate butyrate and combinations thereof to hydroxypropyl cellulose is in the range of about 97/3 to about 50/50;
- and forming a chewable tablet by compressing the coated medicament in the presence of excipients.
A method for taste masking medicaments comprising coating a medicament composition with a taste masking effective amount of a polymer blend of cellulose acetate, cellulose acetate butyrate, or combination thereof and hydroxypropyl cellulose.
A method of providing sustained release of a medicament comprising coating a medicament with a sustained release effective amount of a polymer blend of cellulose acetate, cellulose acetate butyrate or combination thereof and hydroxypropyl cellulose.
Dependencies are inferred from the claim text.