Mono-iodopropargyl esters of dicarboxylic anhydrides and their use as antimicrobial agents

Abstract

The new compositions of matter of the present invention comprise compounds having one of the following formulas: ##STR1## wherein: R is hydrogen or methyl; n is 1 to 16; R.sub.1 and R.sub.2 are defined as R.sub.3 and R.sub.4 below or are joined to form a cycloalkyl, cycloalkenyl, aromatic or a heterocyclic ring containing an oxygen, nitrogen or sulfur atom or an alkoxy, amino, carboxyl, halo, hydroxyl, keto or a thiocarboxyl substituted derivative thereof; R.sub.3 and R.sub.4 are independently selected from (A) hydrogen, alkyl, cycloalkyo, alkenyl, cycloalkenyl, aryl, a heterocyclic ring containing an oxygen, nitrogen or sulfur atom, alkoxy, amino, carboxyl, halo, hydroxyl, keto or a thiocarboxyl and (B) substituted derivatives of the alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl and the heterocyclic ring wherein the substitutions are alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, alkoxy, amino, carboxyl, halo, hydroxyl, keto or a thiocarboxyl; W may be a single bond, oxygen, NR.sub.5, or (CR.sub.6 R.sub.7).sub.m, wherein R.sub.5 is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl or a heterocyclic ring containing an oxygen, nitrogen or sulfur atom or a substituted derivative of alkyl, cycloalkyl, alkenyl, cycloalkenyl or aryl groups wherein the substitutions are alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, alkoxy, amino, carboxyl, halo, hydroxyl, keto or a thiocarboxyl where R.sub.6 and R.sub.7 are defined as R.sub.3 and R.sub.4 above and m is an integer from 1 to 12; and X is hydrogen or a salt-forming cation. Examples of such compositions are mono-iodopropargyl succinates, maleates, itaconates, diglycolates and phthalates. Other compounds include the mono-iodopropargyl esters of anhydrides such as dimethylglutaric anhydride and ethylenediamine tetraacetic dianhydride. They are used in microbiocidal formulations and effective microbiocides.

Dependencies are inferred from the claim text.