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US 5,073,543 AGranted
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
AssigneeG. D. Searle & Co.
InventorsLucia G. I. Marshall, Kanaiyalal R. Patel, Dikla G. Roufa
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Abstract
A formulation is described for systemic delivery and controlled release of a trophic factor. The formulation comprises a glycolipid carrier component which delivers trophic factor, such as nerve growth factor, to a target organ. The glycolipid carrier protects the trophic factor from degradation by enzymes typically endogenous to the human body.
Claims7
A method for administering systemically a therapeutically-effective amount of a trophic factor to a mammal for treatment of a neurodegenerative disease, said method comprising administering a formulation comprised of:
- (a) a therapeutically effective amount of a trophic factor selected from NGF, .beta.-NGF and des 1-9 NGF, for treating a neurodegenerative disease or for regenerating neuronal tissue or for protecting neural tissue from damage induced by chemical, metabolic, mechanical or viral agents or by radiation;
- and
- (b) a carrier comprising a phospholipid component and a ganglioside component selected from GM.sub.1, GD.sub.1 and GT.sub.1 ganglioside types, said carrier containing said trophic factor;
- whereby a formulation is provided capable of slowly releasing the trophic factor or protecting the trophic factor from degradative enzymes.
1 more element
Dependencies are inferred from the claim text.