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US 5,073,379 AGranted
Continuous preparation of solid pharmaceutical forms
AssigneeBASF SE
InventorsRoger Klimesch, Gerhard Bleckmann, Karl-Peter Farwerck, Lothar Schlemmer, Axel Sanner
Life of this patent
Estimating the term…
Abstract
A mixture of one or more pharmaceutical active compounds and one or more thermoplastic polymers is tabletted by a process in which the mixture is extruded and the still moldable extrudate is pressed to give tablets, between two belts, or a belt and a roller, which make contact in parts, rotate in opposite directions and run parallel along the contact zone, the shape-imparting indentations, which may be present in complementary pairs, being located in both or in only one of the revolving shape-imparting elements.
Claims20
A process for tabletting a mixture of
- one or more pharmaceutical active compounds,
- one or more pharmacologically acceptable thermoplastic polymers, said polymers having a Fikentscher K value of from 10 to 100, and
- optional pharmaceutical auxiliaries,
- said mixture having a glass transition temperature below the decomposition temperature of all components of said mixture
- wherein said mixture is heated, without thermal and/or oxidative degradation, at a temperature of from 50.degree. to 180.degree. to render the mixture extrudable and said heated mixture is extruded at from 50.degree. to 180.degree. and the still formable extrudate is pressed between two belts or a belt and a roller to give tablets, said two belts or said belt and a roller making contact in parts, rotating in opposite directions and running parallel along a contact zone, at least one of said two belts or at least one of said belt and a roller having shape-imparting indentations.
2 more elements
Dependencies are inferred from the claim text.