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US 5,071,965 AGranted
Novel TC-99M complexes
AssigneeMallinckrodt Medical, Inc.
InventorsT. Jeffrey Dunn, Dennis Nosco, Steven Woulfe, Richard Dean, Dennis Wester
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Abstract
Complexes useful as radiopharmaceutical imaging agents comprise technetium bonded to a ligand which generally can be described by the formula: ##STR1## wherein Z is N, C, B or P; the three Y groups can be the same or different, each characterized by the general formula ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, W, and X are further defined herein.
Claims1
A complex useful as a radiopharmaceutical imaging agent comprising technetium in the + 4 oxidation state bonded to a ligand having the formula:
- ##STR72## wherein Z is C, and the three Y groups are characterized by the general formula. ##STR73## wherein R.sup.1 and R.sup.2 taken together with the carbon atoms to which they are directly attached, form an aryl group, R.sup.3 is H, R.sup.4 is CH.sub.2 OCH.sub.2 CH.sub.2 CH.sub.3, each of R.sup.5, R.sup.6, R.sup.7, and R.sup.8 is H and W is CH.sub.2 such that y has the general formula ##STR74## wherein X is OH.
Dependencies are inferred from the claim text.