Rotavirus nucleocapsid protein VP6 as a carrier in vaccine compositions
AssigneeUniversity of Saskatchewan
InventorsMarta I. Sabara, Patrick J. Frenchick, Kerry F. Mullin-Ready
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Abstract
Immunological carrier complexes are provided utilizing the VP6 polypeptide from rotavirus as the carrier molecule. Also provided are methods of binding epitope-bearing molecules (e.g., haptens) to the VP6 carrier molecule through binding peptides. The VP6 carrier can be a VP6 monomer, oligomer, or a particle containing of VP6 oligomers.
Claims16
An immunological carrier complex that raises an immunological response in a mammal to an epitope said complex comprising:
- an epitope-bearing molecule containing an epitope-bearing moiety selected from the group consisting of polypeptides and carbohydrates coupled to a carrier protein comprising the amino acid sequence of a rotavirus VP6 inner capsid protein.
In a vaccine composition wherein the epitope of interest is on a polypeptide bound to a carrier protein, the improvement comprising using a protein comprising the amino acid sequence of rotavirus VP6 inner capsid protein as said carrier protein.
Dependencies are inferred from the claim text.