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US 5,068,187 AGranted
Process for producing D-.alpha.-amino acids
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsMamoru Takeichi, Naoshi Hagihara, Hitoshi Tarukawa, Shinichirou Tawaki, Nobuyoshi Makiguchi
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Abstract
The 5-substituted hydantoins represented below can be transformed into D-.alpha.-amino acids by the use of the cultured broth, cells or treated cells of the genus Hansenula: 5-substituted hydantoins: ##STR1## wherein R represents an alkyl, substituted alkyl, phenyl or substituted phenyl group. D-.alpha.-amino acids: ##STR2## wherein R represents the same meanings as above.
Claims4
A process for producing D-alpha-amino acid represented by formula (I):
- ##STR13## where R represents a phenyl group;
- a hydroxyphenyl group;
- an unsubstituted C.sub.1 -C.sub.4 alkyl group or a substituted C.sub.1 -C.sub.2 alkyl group wherein the substituent is methylthio, hydroxy, phenyl or indolyl;
- comprising the steps of:
- subjecting a 5-substituted hydantoin represented by formula (II):
- ##STR14## where R represents the same meaning as in the formula (I), to the action of a cultured broth or cells of a microorganism having the ability to microbially transform said hydantoin of formula (II) into a D-.alpha.-amino acid of formula (I), said microorganism being selected from the group consisting of Hansenula ciferrii, Hansenula henricii, Hansenula nonfermentans and Hansenula polymorpha;
- and
- purifying the thus obtained D-.alpha.-amino acid.
5 more elements
Dependencies are inferred from the claim text.