Back to results
US 5,066,436 AGranted
Process for microencapsulation
AssigneeGist-Brocades N.V.
InventorsJoseph Komen, Jan W. Groenendaal
Life of this patent
Estimating the term…
Abstract
A process for microencapsulating bioactive substances in biocompatible polymers according to the phase-separation principle, wherein an excess of an ethyl or isopropyl ester of a straight-chain fatty acid having 12-18 carbon atoms is used as the hardening liquid, and the pharmaceutical compositions containing the microcapsules prepared by this process. Isopropyl myristate and isopropyl palmitate are preferred hardening liquids.
Claims19
A process for microencapsulating bioactive compositions according to the phase separation principle, whereby microcapsules are formed by:
- a. dispersing the bioactive composition in an organic solution of a biocompatible polymer;
- b. adding a coacervation agent to the dispersion;
- c. adding a hardening liquid to the dispersion and
- d. collecting, washing and drying the resultant microcapsules, the improvement comprising adding as the hardening liquid an ethyl or isopropyl ester of a straight chain fatty acid having 12-18 carbon atoms to the dispersion in an excess with respect to the combined volume of solvent and coacervation agent.
1 more element
Dependencies are inferred from the claim text.