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US 5,064,864 AGranted
Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase
AssigneeMerrell Dow Pharmaceuticals Inc.
InventorsEsa T. Jarvi, Michael L. Edwards, James R. McCarthy
Life of this patent
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Abstract
This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.
Claims6
A compound of the formula ##STR7## wherein each dotted line individually represents an optional double bond,
- R.sub.1 is --CH.dbd.CF.sub.2, --CH.dbd.CR.sub.3 R.sub.4 or --R.sub.5 --OH, wherein R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.4 alkyl, and R.sub.5 is a C.sub.1 -C.sub.4 alkylene, and
- each R.sub.2 is independently hydrogen or methyl.
A compound of the formula ##STR8## wherein each dotted line individually represents an optional double bond,
- R.sub.1 is --CH.dbd.CF.sub.2, --CH.dbd.CR.sub.3 R.sub.4 or --R.sub.5 --OH, wherein R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.4 alkyl, and R.sub.5 is a C.sub.1 -C.sub.4 alkylene, and
- each R.sub.2 is independently hydrogen or methyl.
Dependencies are inferred from the claim text.