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US 5,064,811 AGranted
De-mannosyl teicoplanin derivatives
AssigneeGruppo Lepetit S.p.A.
InventorsAngelo Borghi, Giancarlo Lancini, Piero Antonini
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Abstract
The oject of this invention are de-mannosylated teicoplanin derivatives which can be obtained in good yield by microbiological transformation with cultures of Nocardia orientalis NRRL 2450 or Streptomyces candiodus NRRL 3218.
Claims10
A compound of the formula:
- ##STR3## wherein R.sup.1 is represented by N-Z(Z-4-decenoyl)-beta-D-2-deoxy-2-amino-glucpyranosyl, N-(8-methyl-[noanoyl] nonanoyl)-beta-D-2-deoxy-2-amino-glucopyranosyl, N-decanoyl-beta-D-2-deoxy-2-amino-glucopyranosyl, N-(8-methyl-decanoyl)-beta-D-2-deoxy-2-amino-glucopyranosyl, or N-(9-methyl-decanoyl)-beta-D-2-deoxy-2-amino-glucopyranosyl;
- R.sub.1 is N-acetyl-beta-D-2-deoxy-[2-deoxy0]2-amino-glucopyranosyl;
- R.sub.2 is hydrogen;
- or an acidic or basic addition salt thereof.
1 more element
Dependencies are inferred from the claim text.