Blood compatible, lubricious article and composition and method therefor
AssigneeBecton, Dickinson and Company
InventorsDonald D. Solomon, Robert A. Taller, Victor A. Williamitis
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Abstract
A leach resistant composition includes a quaternary ammonium complex of heparin and a silicone. A method for applying a coating of the composition to a surface of a medical article is within the purview of the present invention. Medical articles having surfaces which are both lubricious and antithrombogenic, are produced in accordance with the method hereof.
Claims6
A medical device for contact with a blood stream comprising an article having coated thereon a composition comprising a mixture of a quaternary ammonium complex of heparin and about 2 to 75% by weight of a noncuring lubricating silicone, said complex having the formula ##STR3## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently selected from the group consisting of an alkyl group of 1 to about 18 carbon atoms and an aralkyl group of about 7 to 18 carbon atoms and H.sup.- is a negative ion of heparin, said silicone having a viscosity of about 20 to 1,000,000 centistokes.
Dependencies are inferred from the claim text.