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US 5,057,302 AGranted
Bifunctional chelating agents
AssigneeAbbott Laboratories
InventorsDavid K. Johnson, Steven J. Kline
Life of this patent
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Abstract
The present invention provides bifunctional chelating agents comprising a unique substrate reactive moiety incorporated into a carboxymethyl arm of a polyaminopolycarboxylate chelating framework capable of forming stable complexes with metal ions.
Claims29
A substrate conjugate of the formula:
- ##STR15## wherein Q is a substrate molecule and wherein X is meta or para and is a residue of a substrate reactive moiety;
- wherein n=0 to about 10;
- wherein R.sub.1 is selected from the group consisting of:
- --(CH.sub.2)q--,
- --[(CH.sub.2).sub.q N(R.sub.5)(CH.sub.2).sub.r ]--,
- --[(CH.sub.2).sub.q O(CH.sub.2).sub.r O(CH.sub.2).sub.s ]--,
- --[(CH.sub.2).sub.q N(R.sub.5)(CH.sub.2).sub.r N(R.sub.6)(CH.sub.2).sub.s ]--, ##STR16## wherein q=2 or 3, r=2 or 3, and
- s=2 or 3;
- wherein R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of:
- hydrogen
- CH.sub.2 CO.sub.2 H
- ortho-CH.sub.2 C.sub.6 H.sub.4 OH, and
- wherein when R.sub.1 =(CH.sub.2).sub.q
- R.sub.2 and R.sub.3 may be fused to form a hydrocarbyl ring of the formula
- --(CH.sub.2).sub.t N(R.sub.7)(CH.sub.2).sub.u N(R.sub.8)(CH.sub.2).sub.v --
- wherein t=2 or 3,
- u=2 or 3, and
- v=2 or 3
- wherein R.sub.7 and R.sub.8 are selected from the group consisting of:
- hydrogen,
- --CH.sub.2 CO.sub.2 H, and
- ortho--CH.sub.2 C.sub.6 H.sub.4 OH.
19 more elements
A substrate metal ion conjugate of the formula:
- ##STR21## wherein Q is a substrate molecule;
- wherein M is a metal ion;
- wherein X is meta or para and is a residue of a substrate reactive moiety;
- wherein n=0 to about 10;
- wherein R.sub.1 is selected from the group consisting of:
- --(CH.sub.2).sub.q --,
- --[(CH.sub.2).sub.q N(R.sub.5)(CH.sub.2).sub.r ]--,
- --[(CH.sub.2).sub.q O(CH.sub.2).sub.r O(CH.sub.2).sub.s ]--,
- --[(CH.sub.2).sub.q N(R.sub.5)(CH.sub.2).sub.r N(R.sub.6)(CH.sub.2).sub.s ]--, ##STR22## wherein q=2 or 3, r=2 or 3, and
- s=2 or 3;
- wherein R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are the same or different and are selected from the group consisting of:
- hydrogen
- CH.sub.2 CO.sub.2 H
- ortho-CH.sub.2 C.sub.6 H.sub.4 OH, and
- wherein when R.sub.1 =(CH.sub.2).sub.q
- R.sub.2 and R.sub.3 may be fused to form a hydrocarbyl ring of the formula
- --(CH.sub.2).sub.t N(R.sub.7)(CH.sub.2).sub.u N(R.sub.8)(CH.sub.2).sub.v --
- wherein t=2 or 3,
- u=2 or 3, and
- v=2 or 3
- wherein R.sub.7 and R.sub.8 are selected from the group consisting of:
- hydrogen,
- --CH.sub.2 CO.sub.2 H, and
- ortho-CH.sub.2 C.sub.6 H.sub.4 OH.
21 more elements
Dependencies are inferred from the claim text.