Spirocyclic 6-amido carbapenems
AssigneeMerck & Co., Inc.
InventorsMark L. Greenlee, Frank P. DiNinno, Thomas N. Salzmann
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Abstract
Provided are new antibacterial spirocyclic 6-amido carbapenems of the formula: ##STR1## wherein: R.sup.1 is hydrogen, C.sub.1-8 substituted or unsubstituted alkyl or C.sub.6-10 substituted or unsubstituted aryl; R.sup.2 is hydrogen, C.sub.1-8 substituted or unsubstituted alkyl or C.sub.2-8 substituted or unsubstituted acyl; R.sup.3 is hydrogen, C.sub.1-8 substituted or unsubstituted thioalkyl or C.sub.6-10 substituted or unsubstituted thioaryl, or 5 or 6 membered substituted or unsubstituted thioheteroaryl; and R.sup.4 is hydrogen, pharmaceutically acceptable alkali metal salt or biolabile ester, and a process for their synthesis through novel intermediates.
Claims9
A compound of the structural formula:
- wherein R.sup.1 is hydrogen, C.sub.1-8 alkyl or C.sub.6-10 aryl;
- R.sup.2 is hydrogen, C.sub.1-8 alkyl or C.sub.2-8 acyl;
- R.sup.3 is hydrogen, --CN substituted or unsubstituted C.sub.1-8 alkylthio, C.sub.6-10 arylthio, or pyrid-2-ylthio;
- and R.sup.4 is hydrogen, pharmaceutically acceptable alkali metal salt or biolabile ester.
Dependencies are inferred from the claim text.