Biphenyl derivative composition for nerve cell degeneration repairing or protective agent and process for preparing a phenyl derivative contained in the composition
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsTatsuyoshi Tanaka, Yoji Sakurai, Hiroshi Okazaki, Takashi Hasegawa, Yoshiyasu Fukuyama
Life of this patent
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Abstract
There is disclosed a biphenyl derivative of the formula (B): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and R.sup.c are as defined or its salt, a composition for nerve cell degeneration repairing or protecting agent containing a phenyl derivative selected from compounds (1) to (4) and (B) as defined, and a process for preparing a phenyl derivative contained in the composition.
Claims16
A biphenyl derivative or a salt thereof, represented by the general formula (B):
- ##STR96## wherein R.sup.1 and R.sup.5 are lower alkenyl groups, R.sup.3 is a hydroxyl group, a lower alkoxy group, a hydrogen atom, a lower alkyl group which may have a lower alkoxy group or hydroxyl group as a substituent, a lower alkenyl group, a cycloalkenyl group, a phenyl group, a halogen atom, a lower alkanoyl group which may have a halogen atom as a substituent, a thiazolyl group which may have a lower alkyl group as a substituent, group:
- ##STR97## (where A is a lower alkylene group, R.sup.7 and R.sup.8 are the same or different, a hydrogen atom, lower alkyl group or lower alkanoyl group, these R.sup.7 and R.sup.8 together with nitrogen atom to which R.sup.7 and R.sup.8 are bonded may form a saturated or unsaturated heterocyclic 5- or 6-membered ring with or without a nitrogen atom or an oxygen atom, and said ring may have an amide group which may have a lower alkyl group as a substituent or an oxo group), or group:
- ##STR98## (where R.sup.7a, R.sup.7b and R.sup.7c are lower alkyl groups, A is a lower alkylene group), R.sup.4 is a hydrogen atom, a lower alkyl group which may have a hydroxyl group or a lower alkoxy group as a substituent, a lower alkoxy group, a phenyl group, a phenyl-lower alkyl group, a phenoxy group, a lower alkenyl group, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, a halogen atom, a lower alkoxy-lower alkyl group or a lower alkanoyl group, R.sup.c is a hydrogen atom or a lower alkyl group.
3,3'-diallyl-5-ethyl-2,4'-biphenyldiol
3,3'-diallyl-5-ethyl-5'-fluoro-2,4'-biphenyldiol.
3,3'-diallyl-5-methylthio-2,4'-biphenyldiol.
3,3',5,5'-tetraallyl-2,4'-biphenyldiol.
3,3'-diallyl-5-ethyl-5'-phenyl-2,4'-biphenyldiol.
Dependencies are inferred from the claim text.