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US 5,053,489 AGranted
Genetically engineered polypeptides with determinants of the human DF3 breast carcinoma-associated antigen
AssigneeDana-Farber Cancer Institute, Inc.
InventorDonald W. Kufe
Life of this patent
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Abstract
A carbohydrate-free polypeptide coded for by a human DNA sequence of 309 nucleotides is immunologically reactive with monoclonal antibody against the human DF3 breast carcinoma-associated antigen. The nucleotide sequence is also useful as a probe to reveal restriction fragment length polymorphisms in human DNA.
Claims7
A polypeptide that:
- (1) is free or substantially free of bound carbohydrate;
- and
- (2) includes all or a portion of an amino acid sequence that is coded for by a double stranded DNA molecule containing in one strand a first nucleotide sequence ##STR2## and containing in the other strand a second nucleotide sequence complementary to the first nucleotide sequence.
Dependencies are inferred from the claim text.