Multiple polymer synthesizer
AssigneeSRI International
InventorAmrit K. Judd
Life of this patent
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Abstract
An apparatus for simultaneously performing a multiplicity of synthesis reactions is disclosed. The synthesizer includes at least one reaction vessel having an access port and a synthesis compartment adjacent the access port. A closable exit channel with an exit port is adjacent the synthesis compartment. The apparatus also includes a base having a plurality of inlets, each of the inlets configured to receive the exit channel of the reaction vessel. A fluid outlet is present that is in communication with the plurality of inlets. A vacuum pump and vacuum line are connected to the fluid outlet for sucking excess reagents and by-products from the reaction vessel. The apparatus further includes a shaker for shaking the reaction vessel while synthesis is proceeding.
Claims19
An apparatus for simultaneously performing a multiplicity of solid phase synthesis chemical reactions, said apparatus comprising:
- a plurality of reaction vessels, each of said reaction vessels having an access port, each of said reaction vessels including a synthesis compartment in communication with the access port and a closable exit channel in communication with said synthesis compartment and disposed opposite said access port with respect to said synthesis compartment, said closable exit channel with an exit port;
- a base having a plurality of inlets, each of said inlets configured to receive said exit channel of one said reaction vessel;
- a fluid outlet connected to said base and in communication through said base with said plurality of inlets;
- pressure changing means in association with said fluid outlet for changing the pressure in said reaction vessel;
- and
- shaking means for shaking each of said reaction vessels.
An apparatus for simultaneously performing a multiplicity of solid phase synthesis chemical reactions, said apparatus comprising:
- a plurality of reaction vessels, each of said reaction vessels having an access port, each of said reaction vessels including a synthesis compartment in communication with the access port and a closable exit channel in communication with said synthesis compartment and disposed opposite said access port with respect to said synthesis compartment, said closable exit channel with an exit port;
- a base comprising (a) a first platform, said first platform having a plurality of inlets, each of said inlets configured to receive said exit channel of one said reaction vessel, (b) a second platform which includes an orifice to which each of said inlets is connected, (c) guide walls defining a surface of said second platform, said guide walls tapering toward said orifice, (d) a fluid outlet disposed upon said second platform and in communication with said plurality of inlets, and (e) a fluid channel adjacent said fluid outlet, said fluid channel disposed between said orifice and said fluid outlet;
- a vacuum pump nd a vacuum line connected to said vacuum pump and to said fluid outlet and positioned between said vacuum pump and said fluid outlet;
- and
- shaking means for shaking each of said reaction vessels.
Dependencies are inferred from the claim text.